반응 #1118663

반응 방정식

piperazine

2-bromo-3-methoxypyridine

→

1-(3-methoxy-2pyridinyl)piperazine

수율 82.0%

용매

반응 조건

후처리

1. 1
   온도Upon cooling
2. 2
   추출extracted with CH2Cl2 (3×50 mL)
3. 3
   기타The extracts were dried
4. 4
   여과filtered
5. 5
   농축concentrated under reduced pressure

실험 절차

Anhydrous piperazine (45.6 g) and 2-bromo-3-methoxypyridine (10.0 g) were heated neat in an autoclave at 100° C. for 20 h. Upon cooling, the mixture was treated with 5% NaCO3 (20 mL) and extracted with CH2Cl2 (3×50 mL). The extracts were dried using anhydrous K2CO3, filtered, and concentrated under reduced pressure to yield 1-(3-methoxy-2pyridinyl)piperazine (III; 8.43 g; 82%) after silica gel chromatography (CH2Cl2/MeOH/NH4OH; 93:7:0.7).

출처