반응 #1115249

반응 방정식

4-(benzyloxy)-6-(6-(2,6-difluorophenyl)pyridin-2-yl)quinoline

→

6-(6-(2,6-difluorophenyl)pyridin-2-yl)quinolin-4-ol

수율 70.0%

용매

EtOH EtOAc

반응 조건

후처리

1. 1
   여과At this time the mixture was filtered through a pad of celite
2. 2
   세척eluting with EtOAc
3. 3
   기타The volatiles were removed in vacuo

실험 절차

To a solution of 4-(benzyloxy)-6-(6-(2,6-difluorophenyl)pyridin-2-yl)quinoline (1.0 equiv.) in 1:1 EtOH/EtOAc, at a concentration of 0.1 M, was added 10% palladium on carbon (0.1 eq.). The resultant heterogeneous solution was put under an atmosphere of hydrogen and was stirred for 72 hours. At this time the mixture was filtered through a pad of celite eluting with EtOAc. The volatiles were removed in vacuo yielding 6-(6-(2,6-difluorophenyl)pyridin-2-yl)quinolin-4-ol (70%). LCMS (m/z): 335.0 (MH+); LC Rt=3.09 min.

출처