반응 #1114301

반응 방정식

3-ethoxycarbonyl-7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylic acid

3-Ethoxycarbonyl-7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylic acid

5-fluoro-2H-spiro[benzofuran-3,4′-piperidine]hydrochloride

→

title compound

수율 64.3%

3-Ethoxycarbonyl-6-(5-fluoro-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)-7-hydroxypyrazolo[1,5-a]pyrimidine

수율 64.3%

반응 조건

후처리

1. 1
   기타obtained in Reference Example 3

실험 절차

In the same manner as in Example 1, step 2 and using 3-ethoxycarbonyl-7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.416 g, 1.66 mmol) obtained in Example 19, step 2 and 5-fluoro-2H-spiro[benzofuran-3,4′-piperidine]hydrochloride (0.500 g, 1.99 mmol) obtained in Reference Example 3, the title compound (0.470 g, 54%) was obtained.

출처