반응 #1113088

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4-(2,5-dichloro-phenoxy)-pyrimidine-5-carboxylic acid

1,2,3,4-tetrahydroquinoxaline

→

desired compound

수율 20.0%

[4-(2,5-Dichloro-phenoxy)-pyrimidin-5-yl]-(3,4-dihydro-2H-quinoxalin-1-yl)-methanone

수율 20.0%

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후처리

1. 1
   기타The compound was purified by preparative HPLC (Phenomenex Gemini column)

실험 절차

The title compound was prepared in analogy to Example 77, from 4-(2,5-dichloro-phenoxy)-pyrimidine-5-carboxylic acid (Example 76, intermediate a) and 1,2,3,4-tetrahydroquinoxaline (commercially available, CAS RN 3476-89-9). The compound was purified by preparative HPLC (Phenomenex Gemini column) using a gradient of acetonitrile:water (10:90 to 98:2) to give 16 mg (20%) of the desired compound. MS (ESI): m/z=401.0 [M+H]+.

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