반응 #1107895

반응 방정식

4-amino-2-chloro-6,7-dimethoxyquinazoline

3-methylaminopropionitrile

dimethylformamide

→

N-(4-amino-6,7-dimethoxyquinazol-2-yl)-N-methyl-2-cyanoethylamine hydrochloride

수율 74.2%

용매

isopropanol

반응 조건

후처리

1. 1
   온도cooled to 25° C.
2. 2
   workup.STIRRINGThe reaction mass was further stirred for 15 minutes
3. 3
   여과filtered
4. 4
   세척washed with 50 ml isopropanol
5. 5
   기타to drying at 50° C. for 7-8 hours

실험 절차

50 gms, 0.208 moles of 4-amino-2-chloro-6,7-dimethoxyquinazoline and 21.2 gms, 0.252 moles of 3-methylaminopropionitrile were charged in a round bottom flask containing 350 ml dimethylformamide. The reaction mass was stirred at about 100° C. for 6 hours, cooled to 25° C. and charged with 250 ml isopropanol. The reaction mass was further stirred for 15 minutes, filtered and washed with 50 ml isopropanol and subjected to drying at 50° C. for 7-8 hours to yield N-(4-amino-6,7-dimethoxyquinazol-2-yl)-N-methyl-2-cyanoethylamine hydrochloride (50 gms).

출처