반응 #1107598

반응 방정식

methyl 3-bromo-2-(bromomethyl)benzoate

methyl 6-aminohexanoate hydrochloride

triethylamine

→

title compound

수율 99.0%

methyl 6-(4-bromo-1-oxoisoindolin-2-yl)hexanoate

수율 99.0%

용매

THF

반응 조건

실험 절차

The procedure of the step 2 in Example 1 was repeated except that methyl 3-bromo-2-(bromomethyl)benzoate instead of methyl 3-bromo-2-(bromomethyl)-4,5-dimethoxybenzoate, methyl 6-aminohexanoate hydrochloride instead of methyl 4-(aminomethyl)benzoate hydrochloride, triethylamine (2.4 equiv.), and THF as a solvent were used and the reaction was conducted for 20 hrs, to obtain the title compound (99%).

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