반응 #1106681

반응 방정식

Benzo[1,3]dioxole-2-carboxylic acid amide

Lithium aluminum hydride

water

→

C-benzo[1,3]dioxol-2-yl-methylamine

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타to destroy the excess LAH
2. 2
   workup.ADDITIONAqueous sodium hydroxide (3.0 M, 100 mL) was added
3. 3
   추출the solution was extracted with ethyl acetate (3×100 mL)
4. 4
   세척The combined organic solution was washed with water
5. 5
   건조dried over MgSO4
6. 6
   기타The solvent was evaporated

실험 절차

Benzo[1,3]dioxole-2-carboxylic acid amide (5.44 g, 32.9 mmol) was dissolved in tetrahydrofuran (THF, 100 mL). Lithium aluminum hydride (LAH, 1M in THF, 39.5 mL, 39.5 mmol) was added slowly to the solution at room temperature. The reaction was stirred at room temperature for 24 hours. Distilled water was added to destroy the excess LAH. Aqueous sodium hydroxide (3.0 M, 100 mL) was added and the solution was extracted with ethyl acetate (3×100 mL). The combined organic solution was washed with water and dried over MgSO4. The solvent was evaporated to yield C-benzo[1,3]dioxol-2-yl-methylamine as a colorless oil.

출처