반응 #1106678

반응 방정식

((3,4-Dihydro-2H-benzo[b][1,4]dioxepin-3-yl)methyl)amine

sulfamide

Chloroform

→

title compound

((3,4-Dihydro-2H-benzo[b][1,4]dioxepin-3-yl)methyl)sulfamide

용매

dioxane

반응 조건

후처리

1. 1
   온도heated
2. 2
   온도to reflux overnight
3. 3
   기타the precipitate was removed by filtration
4. 4
   농축The filtrate was concentrated under vacuum
5. 5
   기타purified by chromatography (2% to 8% acetone in dichloromethane)

실험 절차

((3,4-Dihydro-2H-benzo[b][1,4]dioxepin-3-yl)methyl)amine (2.90 g, 16.2 mmol) and sulfamide (3.11 g, 32.4 mmol) were combined in dry dioxane (60 ml) and heated to reflux overnight. Chloroform was added and the precipitate was removed by filtration. The filtrate was concentrated under vacuum and purified by chromatography (2% to 8% acetone in dichloromethane) to yield the title compound as an off-white solid.

출처