반응 #1106675

반응 방정식

3-bromo-5-tert-butylbenzaldehyde

malonic acid

ammonium acetate

→

product

수율 51.6%

3-amino-3-(3-bromo-5-tert-butylphenyl)propionic acid

수율 51.6%

용매

isopropanol

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux under nitrogen for 3 h
3. 3
   기타to afford a thick colorless solid
4. 4
   여과The solid was filtered hot
5. 5
   세척washed with hot isopropanol (2×25 mL)
6. 6
   기타dried in vacuo

실험 절차

A suspension of 3-bromo-5-tert-butylbenzaldehyde (4.17 g, 17.30 mmol), malonic acid (2.15 g, 20.72 mmol) and ammonium acetate (2.66 g, 34.59 mmol) in isopropanol (35 mL) was heated at reflux under nitrogen for 3 h to afford a thick colorless solid. The solid was filtered hot, washed with hot isopropanol (2×25 mL) and dried in vacuo to give the desired racemic product as a colorless solid (2.68 g).

출처