반응 #1106537

반응 방정식

piperidinecarboxylic acid, ethyl ester

MeOH

sodium methoxide

→

piperidinecarboxylic Acid, Methyl Ester

용매

THF

반응 조건

후처리

1. 1
   온도at reflux
2. 2
   세척the resin was washed
3. 3
   기타dried under vacuum

실험 절차

Polymer-bound piperidinecarboxylic acid, ethyl ester resin (0.25 g, 0.283 mmol) was swollen with a solution of MeOH (1 ml) in THF (4 ml) in a QUICKFIT test-tube. After addition of sodium methoxide (0.28 ml, 0.028 mmol, 1M solution in MeOH) the resulting suspension was stirred overnight at reflux. The reaction suspension was cooled down to room temperature and the resin was washed using VACMASTER station with DCM (4×3 ml), MeOH (2×3 ml) and then dried under vacuum. FT-IR (2% w/w KBr disk): C=0 1736 cm−1 (ester); 163 cm−1 (amide).

출처