반응 #11043

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Ethyl 3-{[(3′-{[(2-aminoanilino)carbothioyl]amino}[1,1′-biphenyl]-3-yl)sulfonyl]amino}-3-phenyl-propanoate

→

Ethyl 3-{[3′-(1H-benzimidazol-2-ylamino)[1,1′-biphenyl]3-yl]-sulfonylamino}-3-phenyl-propanoate

용매

CHCl3

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후처리

1. 1
   온도refluxed for 6 h
2. 2
   기타The resulting material was purified via flash chromatography (dichloromethane/acetic acid ethyl ester 3+1)
3. 3
   기타Recrystallization from acetic acid ethyl ester

실험 절차

43 g (75 mmol) of Ethyl 3-{[(3′-{[(2-aminoanilino)carbothioyl]amino}[1,1′-biphenyl]-3-yl)sulfonyl]amino}-3-phenyl-propanoate 11.1.1 and 16.24 g (75 mmol) of yellow mercury oxide were mixed with 1.51 CHCl3 and refluxed for 6 h. The resulting material was purified via flash chromatography (dichloromethane/acetic acid ethyl ester 3+1). Recrystallization from acetic acid ethyl ester led to 27.8 g (68%).

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