반응 #1100081

반응 방정식

hydrogen

compound 1-3-3-9

1-(2,3-difluoro-4-ethoxy-6-methylphenyl)-2-(4-(4-propylcyclohexyl)cyclohexyl)ethene

→

1-(2,3-difluoro-4-ethoxy-6-methylphenyl)-2-(4-(4-propylcyclohexyl)cyclohexyl)ethane

수율 80.7%

용매

toluene

반응 조건

후처리

1. 1
   기타was not absorbed
2. 2
   기타Pd/C was removed
3. 3
   workup.DISTILLATIONthe solvent was distilled off
4. 4
   기타The residue was purified by silica gel column chromatography and recrystallization

실험 절차

0.31 g of Pd/C was added to 6.20 g of the compound 1-3-3-9 having been dissolved in 50 mL of toluene and 50 mL of Solmix, and under a hydrogen atmosphere, the mixture was stirred at room temperature until hydrogen was not absorbed. Pd/C was removed, and the solvent was distilled off. The residue was purified by silica gel column chromatography and recrystallization to obtain 5.03 g of 1-(2,3-difluoro-4-ethoxy-6-methylphenyl)-2-(4-(4-propylcyclohexyl)cyclohexyl)ethane (Compound 1-3-3-1) as colorless crystals.

출처