반응 #1099225

반응 방정식

2-{[4-chloro-2-((E)-{4-[ethyl(2-hydroxyethyl)amino]phenyl}-diazenyl)-1,3-thiazol-5-yl]methylene}-1H-indene-1,3(2H)-dione

piperidine

→

2-{[2-((E)-{4-[ethyl(2-hydroxyethyl)amino]phenyl}-diazenyl)-4-(1-piperidinyl)-1,3-thiazol-5-yl]methylene}-1H-indene-1,3(2H)-dione

용매

THF

반응 조건

후처리

1. 1
   온도under reflux for 6 hours
2. 2
   workup.STIRRINGstirring
3. 3
   기타The formed piperidine hydrochloric salt was separated by filtration
4. 4
   기타the solvent removed with a rotary evaporator
5. 5
   workup.ADDITIONThe resulting precipitate containing the crude product
6. 6
   기타was recrystallized with toluene
7. 7
   기타to obtain a dark powder

실험 절차

0.5 g (1.07 mmol) 2-{[4-chloro-2-((E)-{4-[ethyl(2-hydroxyethyl)amino]phenyl}-diazenyl)-1,3-thiazol-5-yl]methylene}-1H-indene-1,3(2H)-dione were dissolved in 20 ml THF. Then 0.2 g (2.14 mmol) piperidine were added dropwise and the mixture was stirred under reflux for 6 hours. After cooling to room temperature, stirring was continued overnight. The formed piperidine hydrochloric salt was separated by filtration and the solvent removed with a rotary evaporator. The resulting precipitate containing the crude product was recrystallized with toluene to obtain a dark powder.

출처