반응 #1096313

ord-05dfd88bdfad402db823386a962415d2

반응 방정식

COC(=O)[C@@H](CI)C(=O)OC(C)(C)C
(R)-methyl 2-(tert-butoxycarbonyl)-3-iodopropanoate
FC(F)(F)c1nccc(Cl)n1
4-chloro-2-(trifluoromethyl)pyrimidine
→
COC(=O)[C@H](Cc1ccnc(C(F)(F)F)n1)C(=O)OC(C)(C)C
title compound
COC(=O)[C@H](Cc1ccnc(C(F)(F)F)n1)C(=O)OC(C)(C)C
(S)-methyl 2-(tert-butoxycarbonyl)-3-(2-(trifluoromethyl)pyrimidin-4-yl)propanoate

반응물

COC(=O)[C@@H](CI)C(=O)OC(C)(C)C
(R)-methyl 2-(tert-butoxycarbonyl)-3-iodopropanoate
FC(F)(F)c1nccc(Cl)n1
4-chloro-2-(trifluoromethyl)pyrimidine

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The title compound was synthesized in a manner analogous to that described Example 475, using (R)-methyl 2-(tert-butoxycarbonyl)-3-iodopropanoate and 4-chloro-2-(trifluoromethyl)pyrimidine.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07973047B2uspto-grants-2011_07