반응 #1095887

반응 방정식

ammonium chloride

4-(2-butynyloxy)-6-chloro-5-fluoropyrimidine

potassium carbonate

3,3,5,5-tetramethylpiperidine hydrochloride

→

4-(2-butynyloxy)-5-fluoro-6-(3,3,5,5-tetramethylpiperidino)pyrimidine

수율 72.3%

용매

acetonitrile

반응 조건

후처리

1. 1
   온도The reaction mixture was cooled to near room temperature
2. 2
   추출the mixture was extracted with tert-butyl methyl ether three times
3. 3
   세척The organic layers were washed with a saturated sodium chloride aqueous solution
4. 4
   건조dried over anhydrous magnesium sulfate
5. 5
   농축concentrated

실험 절차

Into 2 ml of acetonitrile were added 0.20 g of 4-(2-butynyloxy)-6-chloro-5-fluoropyrimidine, 0.54 g of potassium carbonate and 0.30 g of 3,3,5,5-tetramethylpiperidine hydrochloride, and the mixture was stirred for 4 hours at 70° C. The reaction mixture was cooled to near room temperature, a saturated ammonium chloride aqueous solution was added therein, and the mixture was extracted with tert-butyl methyl ether three times. The organic layers were washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 0.22 g of 4-(2-butynyloxy)-5-fluoro-6-(3,3,5,5-tetramethylpiperidino)pyrimidine (hereinafter, referred to as Compound (39)).

출처