반응 #1095853

반응 방정식

4-(2-butynyloxy)-6-chloro-5-fluoropyrimidine

piperidine

→

4-(2-butynyloxy)-5-fluoro-6-piperidinopyrimidine

수율 99.2%

용매

ethanol

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   온도under reflux condition
3. 3
   농축concentrated

실험 절차

Into 3 ml of ethanol was resolved 0.3 g of 4-(2-butynyloxy)-6-chloro-5-fluoropyrimidine, 0.38 g of piperidine was added therein, and the mixture was stirred for 7 hours under reflux condition. The reaction mixture was cooled to near room temperature and concentrated. The residue was subjected to silica gel column chromatography to obtain 0.37 g of 4-(2-butynyloxy)-5-fluoro-6-piperidinopyrimidine (hereinafter, referred to as Compound (2)).

출처