반응 #1095851

반응 방정식

2Q

aminoquinoline

3-(1H-Imidazol-4-yl)propionic acid

CDI

→

N-(2-{[2-(7-Chloro-quinolin-4-ylamino)ethyl]methylamino}ethyl)-3-(1H-imidazol-4-yl)propionamide

수율 23.0%

용매

THF

THF

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   workup.STIRRINGto be stirred
3. 3
   기타After reaction overnight
4. 4
   여과the reaction solution was filtered through a Kiriyama funnel
5. 5
   농축The filtrate was concentrated under a reduced pressure
6. 6
   기타to give a yellow oil
7. 7
   기타this oil was purified by HPLC

실험 절차

3-(1H-Imidazol-4-yl)propionic acid (140 mg, 1 mmol) was dissolved in dist THF, and a condensing agent CDI (200 mg, 1.3 mmol) was added to this solution. The solution was stirred. After two hours, 2Q (278 mg, 1 mmol) dissolved in dist THF was added and continued to be stirred. After reaction overnight, the reaction solution was filtered through a Kiriyama funnel. The filtrate was concentrated under a reduced pressure to give a yellow oil and this oil was purified by HPLC. Yield: 23%

출처