반응 #1094363

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6-chloronicotinoyl chloride

2,4-dimethoxyaniline

→

title compound

수율 59.0%

6-Chloro-N-(2,4-dimethoxyphenyl)-3-pyridinecarboxamide

수율 59.0%

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후처리

1. 1
   여과The reaction mixture was filtered
2. 2
   기타to remove the precipitate
3. 3
   기타the filtrate was evaporated
4. 4
   기타The resulting solid was purified by CH2Cl2/hexane recrystallization
5. 5
   기타to give a light purple solid in a yield of 59%

실험 절차

The title compound was prepared from 6-chloronicotinoyl chloride and 2,4-dimethoxyaniline as described in Example 1. The reaction mixture was filtered to remove the precipitate and the filtrate was evaporated. The resulting solid was purified by CH2Cl2/hexane recrystallization to give a light purple solid in a yield of 59%. 1H NMR (DMSO-d6): 9.77 (s, 1H), 8.93 (s, 1H), 8.35-8.31 (m, 1H), 7.68 (d, J=7.8, 1H), 7.46 (d, J=9.0, 1H), 6.67 (d, J=2.4, 1H), 6.57-6.53 (m, 1H), 3.80 (s, 3H), 3.78 (s, 3H).

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