반응 #10933
ord-96ae0b4ef29e47f48fb533915a460abe
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1workup.ADDITIONwere added into the reaction mixture
- 2여과The produced solid was filtered under a reduced pressure
- 3세척while washing with hexane
- 4기타recrystallized in 100% ethanol
실험 절차
Methyl 3-tetrahydropyrrolyl-2-butenoate (29.0 g, 171.3 mmol) and N-(bromomethyl)phthalimide (43 g, 179.91 mmol) were dissolved in 250 ml of dimethylformamide, and the resulting mixture was then stirred at room temperature for 16 hours under a nitrogen atmosphere. After checking completion of the reaction with TLC, 1N HCl and water were added into the reaction mixture. The produced solid was filtered under a reduced pressure while washing with hexane and then recrystallized in 100% ethanol, thereby to obtain the desired product (32.26 g, 68%).