반응 #1093138

반응 방정식

water

2-mercaptobenzimidazole

5-bromopentanol

triethylamine

→

title compound

수율 75.0%

2-(5-Hydroxypentylthio)benzimidazole

수율 75.0%

용매

acetonitrile

반응 조건

후처리

1. 1
   온도The reaction mixture was cooled
2. 2
   추출extracted with ethyl acetate
3. 3
   건조The extract was dried over sodium sulfate
4. 4
   기타the solvent was evaporated under reduced pressure
5. 5
   기타The resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane)

실험 절차

1.5 g of 2-mercaptobenzimidazole and 1.7 g of 5-bromopentanol were refluxed for 5 hours in an acetonitrile solvent containing 1.2 g of triethylamine. The reaction mixture was cooled, then added with water and extracted with ethyl acetate. The extract was dried over sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane) to obtain 1.77 g of the title compound (yield: 75%).

출처