반응 #1093

반응 방정식

N-tert-butyl-2-methoxycarbonyl-5-nitrobenzenesulfonamide

hydrogen

→

N-tert-Butyl-5-amino-2-methoxycarbonylbenzenesulfonamide

용매

MeOH

반응 조건

후처리

1. 1
   기타The catalyst is separated off
2. 2
   기타the solvent is removed by distillation
3. 3
   기타to crystallize

실험 절차

25.08 g (0.079 mol) of N-tert-butyl-2-methoxycarbonyl-5-nitrobenzenesulfonamide are dissolved in 1000 ml of MeOH. 0.50 g of Pd--C (10%) is added and the mixture is shaken under a hydrogen atmosphere (1 atm) until the uptake of hydrogen has finished. The catalyst is separated off and the solvent is removed by distillation. The residue is induced to crystallize by stirring with a little ethyl acetate. The resulting N-tert-butyl-5-amino-2-methoxycarbonylbenzenesulfonamide (18.3 g; 80.9% of theory) melts at 193° C.

출처