반응 #10922

ord-481e7c54b6434612a675d5ca6d8123d4

반응 방정식

CC(C)(C)OC(=O)NC[C@H]1CN(c2ccc(I)cc2)C(=O)O1
tert-butyl [(5S)-3-(4-iodophenyl)-2-oxo-1,3-oxazolidin-5-yl]methylcarbamate
CC(=O)NC[C@H]1CN(c2ccc(I)c(F)c2)C(=O)O1
N-{[(5S)-(3-fluoro-4-iodophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide
→
CC(=O)NC[C@H]1CN(c2ccc(C3CCC(=O)NC3)cc2)C(=O)O1
N-({(5S)-2-oxo-3-[4-(6-oxopiperidin-3-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)acetamide

반응물

CC(C)(C)OC(=O)NC[C@H]1CN(c2ccc(I)cc2)C(=O)O1
tert-butyl [(5S)-3-(4-iodophenyl)-2-oxo-1,3-oxazolidin-5-yl]methylcarbamate
CC(=O)NC[C@H]1CN(c2ccc(I)c(F)c2)C(=O)O1
N-{[(5S)-(3-fluoro-4-iodophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

N-({(5S)-2-oxo-3-[4-(6-oxopiperidin-3-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)acetamide is prepared by the route described in Example 1 substituting tert-butyl [(5S)-3-(4-iodophenyl)-2-oxo-1,3-oxazolidin-5-yl]methylcarbamate for N-{[(5S)-(3-fluoro-4-iodophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide. 1H-NMR (DMSO) δ: 8.24, 7.51, 7.47, 7.33, 4.71, 4.10, 3.72, 3.40, 3.18, 3.14, 2.97, 2.28, 1.94, 1.83

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07094900B2uspto-grants-2006_08