반응 #1091505

반응 방정식

water

5-methylbenzoxazole

N-bromosuccinimide

→

5-Bromomethylbenzoxazole

용매

chloroform

반응 조건

후처리

1. 1
   온도was refluxed for 2 hours
2. 2
   기타The organic phase was separated
3. 3
   추출the aqueous phase extracted with dichloromethane (30 ml)
4. 4
   세척The combined organic phases were washed with brine (30 ml)
5. 5
   건조dried over magnesium sulphate
6. 6
   기타evaporated
7. 7
   기타The residue was triturated with pentane giving the title compound (0.36 g) as an off-white solid, m.p. 90-93° C.

실험 절차

A solution of 5-methylbenzoxazole (0.5 g) in chloroform (20 ml) containing N-bromosuccinimide (0.18 g) and azoisobutyronitrile (0.05 g) was refluxed for 2 hours. After allowing to cool to room temperature the reaction mixture was treated with water (30 ml). The organic phase was separated and the aqueous phase extracted with dichloromethane (30 ml). The combined organic phases were washed with brine (30 ml), dried over magnesium sulphate and evaporated. The residue was triturated with pentane giving the title compound (0.36 g) as an off-white solid, m.p. 90-93° C.

출처