반응 #10911

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cyanamide

1-(4-isothiocyanatophenyl)-4-cyclopropylmethylpiperazine

1-(4-Isothiocyanatophenyl)-4-(1-cyclopropylmethyl)piperazine

2-bromo-1-(3-difluoro-methoxyphenyl)ethanone

2-Bromo-1-(3-difluoromethoxy-phenyl)ethanone

→

{4-Amino-2-[4-(4-cyclopropylmethyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-difluoromethoxy-phenyl)-methanone

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실험 절차

This compound was prepared from cyanamide, 1-(4-isothiocyanatophenyl)-4-cyclopropylmethylpiperazine (of Example 14G) and 2-bromo-1-(3-difluoro-methoxyphenyl)ethanone (of Example 14L) following the procedure used in Example 24. Mass spectrum (ES) MH+=500.

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