반응 #1090778

반응 방정식

sodium hydroxide

2-amino-5-trifluoromethylpyridine

bromine

→

2-Amino-3-bromo-5-trifluoromethylpyridine

용매

ether

acetic acid

반응 조건

후처리

1. 1
   세척washed successively with saturated potassium carbonate, saturated Na2SO3 and brine
2. 2
   기타dried
3. 3
   농축concentrated
4. 4
   기타to provide
5. 5
   여과after filtration

실험 절차

To a solution of 2-amino-5-trifluoromethylpyridine (9 g) in acetic acid (75 mL) at r.t. was added bromine (5.8 mL) slowly. After 1 h, the acid was neutralized by the careful addition of sodium hydroxide (10 N) at 0° C. The resulting orange precipitate was dissolved in ether and washed successively with saturated potassium carbonate, saturated Na2SO3 and brine, dried and concentrated. The residual solid was stirred vigorously in hexane for 1 h to provide, after filtration, the title compound as a white solid (10.2 g).

출처