반응 #1090429

반응 방정식

ethyl 4-bromobutyrate

2-nitro-3-pyridinol

sodium bicarbonate

→

product ( 40 )

수율 76.0%

Ethyl 4-(2-Nitropyrid-3-yloxy)butyrate

수율 76.0%

용매

methanol methylene chloride

반응 조건

후처리

1. 1
   세척wash of an ether solution of the product
2. 2
   기타to remove traces of starting phenol

실험 절차

This compound was prepared from ethyl 4-bromobutyrate 2 and 2-nitro-3-pyridinol (39) via the procedure of Step (A), supra. Following flash chromatography (silica gel; 1.5% methanol/methylene chloride eluant) a dilute sodium bicarbonate wash of an ether solution of the product was necessary to remove traces of starting phenol. The product (40) was obtained in 76% yield as a pale yelow oil.

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