반응 #1090362

반응 방정식

3-benzyloxy-17α-tert-butyldimethylsilyloxyestra-1,3,5(10)-triene

3-Benzyloxy-17α-tert-butyldimethylsilyloxyestra-1,3,5(10)-triene

→

51

수율 94.0%

17α-tert-butyldimethylsilyloxyestra-1,3,5(10)-trien-3-ol

수율 94.0%

용매

THF

반응 조건

후처리

1. 1
   여과After the catalyst was filtered
2. 2
   기타the solvent was evaporated at reduced pressure
3. 3
   기타The residue was purified by column chromatography (silica gel)

실험 절차

To a solution of 3-benzyloxy-17α-tert-butyldimethylsilyloxyestra-1,3,5(10)-triene (50, 1.90 g, 4.0 mmol) in THF (30 mL) was added 10% palladium on carbon (0.500 g). The reaction mixture was stirred for 2 h under a hydrogen atmosphere at room temperature. After the catalyst was filtered, the solvent was evaporated at reduced pressure. The residue was purified by column chromatography (silica gel) using n-hexane:EtOAc (10:1→5:1, v/v) to afford 1.45 g of 51 (94% yield) mp: 161-162° C. (silica gel) using n-hexane:EtOAc (10:1→5:1, v/v) to afford 1.45 g of 51 (94% yield) mp: 161-162° C.

출처