반응 #10856

반응 방정식

1,3-dichloroacetone

1,2,4-triazole

→

1,3-bis(1,2,4-triazole-1-yl)-propan-2-on

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실험 절차

According to the Spanish Patent Number ES 549 020 A1 1 mole of 1,3-dichloroacetone is reacted with 2 mole of 1,2,4-triazole, then the 1,3-bis(1,2,4-triazole-1-yl)-propan-2-on obtained with low yield is reacted with 2,4-difluorophenylmagnesium bromide to give fluconazole. The yield is about 45% calculated on the Grignard reagent.

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