반응 #1079950

반응 방정식

cis-Tramadol

→

Tramadol

용매

ethyl acetate

반응 조건

후처리

1. 1
   온도the contents of the vessel heated to 50° l C
2. 2
   기타the product crystallises
3. 3
   세척washed with cold ethyl acetate, 2×25 l

실험 절차

A reactor vessel is charged successively with cis-Tramadol base hydrate (crude) 200 Kg and ethyl acetate 300 l and the contents of the vessel heated to 50° l C. until all solids are in solution. The vessel is then cooled to −5 to 0° C. and the product crystallises. Stirring is continued for two hours and the product is then centrifuged and washed with cold ethyl acetate, 2×25 l. Approximately 165-175 Kg (moist) of cis(+/−) Tramadol base hydrate are obtained from this procedure.

출처