반응 #1078652

반응 방정식

pentafluoropyridine

sodium methoxide

→

4-methoxy-2,3,5,6-tetrafluoropyridine

용매

반응 조건

후처리

1. 1
   세척the reaction was washed with water
2. 2
   건조dried (MgSO4)
3. 3
   기타the solvent was removed in vacuo

실험 절차

To pentafluoropyridine (1.0 g, 5.9 mmol) in petroleum ether (60 mL) at 0° C. was added sodium methoxide (0.32 mg, 5.9 mmol). After stirring for 12 hours at ambient temperature, the reaction was washed with water, dried (MgSO4), and the solvent was removed in vacuo to give 4-methoxy-2,3,5,6-tetrafluoropyridine; NMR (CDCl3) 4.3 ppm.

출처