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4-isothiocyanato-N-(TBDMS)-benzenesulfonamide

4-{5-[7-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-1H-pyrazol-3-ylamino]-benzenesulfonamide

H2O

→

4-[5-(6-Methoxy-benzo[b]Thiophen-3-yl)-1H-pyrazol-3-ylamino]-Benzenesulfonamide

수율 34.0%

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실험 절차

Prepared in 34% yield from 3-acetyl-6-methoxy-benzolblthiophene and 4-isothiocyanato-N-(TBDMS)-benzenesulfonamide analogous to the procedure for 4-{5-[7-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-1H-pyrazol-3-ylamino]-benzenesulfonamide [Example 3(d)]. 1H NMR (300 MHz, DMSO-d6) 6 12.60 (s, 1H), 9.10 (s, 1H), 7.92 (d, 1H, J=8.7Hz), 7.80 (s, 1H), 7.65 (app d, 3H, J=8.7Hz), 7.48 (d, 2H, J=8.1Hz), 7.12 (d, 1H, J 8.7Hz), 7.05 (s, 2H), 6.28 (s, 1H), 3.85 (s, 3H). Anal. (C18H16N4O3S20.35 H2O) C. H, N, S. Calculated C=53.15, H=4.14, N=11.77, S=15.77; found C=53.50, H=4.14, N=13.77, S=15.77.

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