반응 #1076000

반응 방정식

toluene

acetic acid anhydride

7-methoxy-6-amino-4-trifluoromethyl-2-(1H)-quinolone

toluene acetone

→

7-Methoxy-6-acetylamino-4-trifluoromethyl-2-(1H)-quinolone

용매

acetic acid

반응 조건

후처리

1. 1
   기타to react for 2 hours at 20° C

실험 절차

27,85 mg of 7-methoxy-6-amino-4-trifluoromethyl-2-(1H)-quinolone are dissolved in 0,5 ml of glacial acetic acid, mixed with 0.15 ml acetic acid anhydride and made to react for 2 hours at 20° C. After subtracting the solvent, the remainder is cleaned with Flash chromatography (silica gel, toluene/acetone 1:1). Yield: 30.7 mg (99%). Melting point 280° C. (toluene, dec), UV λ max 368 nm, emission max 448 nm, IR 1680 (CO).

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