반응 #1075512

반응 방정식

2-(5-bromo-2-pyrimidinyl)-1-(2,3-dihydro-5-benzofuranyl)-2,3,4,9-tetrahydro-1H-β-carboline

1,2-dimethyl-1H-imidazole

PPh3

K2CO3

NaOH

→

title product

1-(2,3-Dihydro-benzofuran-5-yl)-2-[5-(2,3-dimethyl-3H-imidazol4-yl)-pyrimidin-2-yl]-2,3,4,9-tetrahydro-1H-β-carboline

용매

DMF

반응 조건

후처리

1. 1
   추출The resulting solution was extracted with CH2Cl2 (3×50 mL)
2. 2
   건조dried over Na2SO4
3. 3
   기타Purification by preparative TLC

실험 절차

2-(5-bromo-2-pyrimidinyl)-1-(2,3-dihydro-5-benzofuranyl)-2,3,4,9-tetrahydro-1H-β-carboline (0.45 g, 1.00 mmol), 1,2-dimethyl-1H-imidazole (0.18 g, 1.87 mmol), Pd(OAc)2 (12 mg, 0.05 mmol), PPh3 (26 mg, 0.1 mmol) and K2CO3 (0.28 g, 2 mmol) were stirred in 3.5 mL DMF at 140° C. for 14 hours. The mixture was poured into aqueous 10% NaOH solution (50 mL). The resulting solution was extracted with CH2Cl2 (3×50 mL) and dried over Na2SO4. Purification by preparative TLC yielded the title product as yellow powder.

출처