반응 #1074567

반응 방정식

product

2H-pyran-3,5(4H,6H)-dione

product

3-iodo-4-methylbenzaldehyde

methyl 3-aminocrotonate

→

title compound

수율 45.5%

methyl 4-(3-iodo-4-methylphenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate

수율 45.5%

용매

methanol

반응 조건

후처리

1. 1
   여과the mixture was filtered
2. 2
   세척the filter cake washed with methanol
3. 3
   기타dried

실험 절차

The product from Example 1C (0.34 g, 3.0 mmol), the product from Example 3A (0.74 g, 3.0 mmol) and methyl 3-aminocrotonate (0.35 g, 3.0 mmol) in methanol (8 mL) were heated to 80° C. in a sealed tube for 60 hours. After cooling to ambient temperature, the mixture was filtered and the filter cake washed with methanol and dried to provide the title compound (0.60 g).

출처