반응 #1072995

ord-73ab58048bae4d3aa8012e26b495fcf9

반응 방정식

COc1ccc(C2COCCO2)c2sc(NC(=O)Oc3ccccc3)nc12
(+)-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-carbamic acid phenyl ester
CN[C@H]1CC[C@H](O)CC1
trans-4-methylamino-cyclohexanol
c1ccncc1
pyridine
→
COc1ccc(C2COCCO2)c2sc(NC(=O)N(C)[C@H]3CC[C@H](O)CC3)nc12
(+)-trans-3-(7-[1,4]Dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-1-(4-hydroxy-cyclohexyl)-1-methyl-urea

반응물

COc1ccc(C2COCCO2)c2sc(NC(=O)Oc3ccccc3)nc12
(+)-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-carbamic acid phenyl ester
CN[C@H]1CC[C@H](O)CC1
trans-4-methylamino-cyclohexanol
c1ccncc1
pyridine

시약

없음

용매

ClC(Cl)Cl
chloroform
ClC(Cl)Cl
CHCl3

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

From (+)-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-carbamic acid phenyl ester with trans-4-methylamino-cyclohexanol and pyridine in chloroform. [α]D20=+20.5° (c=1.02, CHCl3), ES-MS m/e (%): 422 (M+H+, 100).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06872833B2uspto-grants-2005_03