반응 #10728

반응 방정식

4-acetyl-benzenesulfonyl chloride

ammonia

→

4-acetyl-benzenesulfonamide

수율 93.0%

용매

acetone

반응 조건

후처리

1. 1
   여과The precipitate was filtered
2. 2
   세척the residue was washed with water
3. 3
   기타dried in vacuo

실험 절차

Ex-26A: To a solution of 4-acetyl-benzenesulfonyl chloride (Hoffman, R. V. Org. Syn. VII, 508; 4.18 g, 19.1 mmol) in acetone (30 mL) was added ammonia (28% in water, 8.2 mL, 57.3 mmol) dropwise at 0° C. The reaction mixture was allowed to stir at 0° C. for 30 min. The precipitate was filtered and the residue was washed with water and dried in vacuo to afford 4-acetyl-benzenesulfonamide as a white solid (3.54 g, 93%). 1H NMR (DMSO-d6) δ 8.10 (d, J=9 Hz, 2H), 8.03 (d, J=9 Hz, 2H), 4.86 (bs, 2H), 2.65 (s, 3H).

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