반응 #1070989

반응 방정식

2-(3-bromo-2-hydroxy-5-methyl-phenyl)-3-(4-nitro-benzyl)-1H-indole-5-carboxamidine

SnCl2

→

3-(4-amino-benzyl)-2-(3-bromo-2-hydroxy-5-methyl-phenyl)-1H-indole-5-carboxamidine

수율 42.0%

용매

HCl

HCl

반응 조건

후처리

1. 1
   온도is heated
2. 2
   온도at reflux for 1 hr
3. 3
   온도The reaction is cooled
4. 4
   기타the residue is isolated
5. 5
   기타purified by reverse phase HPLC (0.01%HCl/acetonitrile) with a 2-90% gradient

실험 절차

A mixture of 2-(3-bromo-2-hydroxy-5-methyl-phenyl)-3-(4-nitro-benzyl)-1H-indole-5-carboxamidine 203 (100 mgs, 0.2 mmol), SnCl2 (100 mgs) and 6N HCl is heated at reflux for 1 hr. The reaction is cooled, let stand for 12-18 h, and the residue is isolated. The residue is taken up in 0.1N HCl and purified by reverse phase HPLC (0.01%HCl/acetonitrile) with a 2-90% gradient to yield 42% of 3-(4-amino-benzyl)-2-(3-bromo-2-hydroxy-5-methyl-phenyl)-1H-indole-5-carboxamidine as a white solid (38 mgs, 0.08 mmol).

출처