반응 #1070953

반응 방정식

butyl lithium

diethyl allyl(5-iodopentyl)malonate

ammonium chloride

→

diethyl allyl(nonyl)malonate

수율 75.0%

용매

THF

반응 조건

후처리

1. 1
   기타The reaction liquid
2. 2
   기타the reaction product was purified as in Referential Example 1

실험 절차

To a THF suspension (2.1 ml) containing copper iodide (0.228 g, 1.2 mmol) was added dropwise at −10° C. butyl lithium (2.4 mmol in 0.88 ml of 2.68M hexane solution). The reaction liquid was heated to 0° C. over 30 minutes and then given diethyl allyl(5-iodopentyl)malonate (0.40 g, 1 mmol), followed by stirring at 0° C. for 5 hours. After addition of a saturated aqueous solution of ammonium chloride, the reaction product was purified as in Referential Example 1. Thus there was obtained 0.234 g of diethyl allyl(nonyl)malonate (yields: 75%). Characteristic Values of diethyl allyl(nonyl)malonate

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