반응 #1070594

반응 방정식

2-bromo-3-methoxy-pyridine

NaCN

→

3-methoxy-pyridine-2-carbonitrile

용매

DMSO

반응 조건

후처리

1. 1
   기타The reaction mixture is evaporated
2. 2
   세척washed with 5% Na2CO3 (aqueous)
3. 3
   건조dried over MgSO4
4. 4
   기타evaporated

실험 절차

A solution of 2-bromo-3-methoxy-pyridine from Example 13a in DMSO is treated with NaCN at 120° C. for 18 h. The reaction mixture is evaporated, the residue is taken into ethyl acetate, washed with 5% Na2CO3 (aqueous), dried over MgSO4 and evaporated to give 3-methoxy-pyridine-2-carbonitrile.

출처