반응 #1069773

반응 방정식

hydroxylamine hydrochloride

2-dimethylaminomethyleneamino-4-(1-fluoro-1-methylethyl)-6-(1cyclopropyl-4-phenyl-1-butylamino) -1,3,5-triazine

→

N-[4-(1-Fluoro1-methylethyl)-6-(1-cyclopropyl-4-phenyl-1-butylamino)-1,3,5-triazin-2-yl]formamide oxime

용매

methanol

반응 조건

후처리

1. 1
   workup.DISTILLATIONAll volatile constituents are carefully distilled off
2. 2
   세척The mixture is washed with water
3. 3
   건조dried over Na2SO4
4. 4
   기타evaporated in vacuo

실험 절차

0.69 g (10 mmol) of hydroxylamine hydrochloride are added with stirring at room temperature to a solution of 1.99 g (5 mmol) of 2-dimethylaminomethyleneamino-4-(1-fluoro-1-methylethyl)-6-(1cyclopropyl-4-phenyl-1-butylamino) -1,3,5-triazine in 20 ml of methanol. The reaction mixture is stirred for 2 hours at room temperature. All volatile constituents are carefully distilled off. The crude product is taken up in methylene chloride. The mixture is washed with water, dried over Na2SO4 and evaporated in vacuo. This gives 1.81 g (93.7% of theory) of N-[4-(1-fluoro -1-methylethyl)-6-(1-cyclopropyl-4-phenyl-1-butylamino)-1,3,5-triazin-1-yl]formamide oxime as pale yellow oil.

출처