반응 #1069756

ord-717244c1029846dabf533e1a83e5a94f

반응 방정식

O
water
OCC(O)CO
glycerol
CC(=O)O.CC(=O)O.NC(=N\CCCCCC/N=C(N)/N=C(\N)Nc1ccc(Cl)cc1)/N=C(\N)Nc1ccc(Cl)cc1
chlorhexidine diacetate
CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
D,L-Menthol
→
N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1
Chlorhexidine

반응물

O
water
OCC(O)CO
glycerol
CC(=O)O.CC(=O)O.NC(=N\CCCCCC/N=C(N)/N=C(\N)Nc1ccc(Cl)cc1)/N=C(\N)Nc1ccc(Cl)cc1
chlorhexidine diacetate
CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
D,L-Menthol
—
Lecithin E-80
—
Tween-80
—
alpha-tocopherol acid succinate

시약

없음

용매

CCO
ethyl alcohol
CC(O)CO
propylene glycol

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    세척A mouthwash (oral rinse) formulation of the present invention
  2. 2
    기타was prepared
  3. 3
    workup.ADDITIONThe resultant stock solution was mixed
  4. 4
    workup.ADDITIONwas added as sweetener
  5. 5
    기타to obtain a suspension
  6. 6
    여과The suspension was then filtered sequentially first through a 0.45 micron

실험 절차

A mouthwash (oral rinse) formulation of the present invention was prepared according to the following method. 7.5 g of Lecithin E-80, 625 mg of chlorhexidine diacetate, 525 mg of Tween-80, 250 mg of D,L-Menthol and 30 mg of alpha-tocopherol acid succinate were dissolved in mixture of 20 ml of absolute ethyl alcohol and 10 ml of propylene glycol. The resultant stock solution was mixed with vigorous stirring with 480 ml of distilled water and 10 g of pure glycerol was added as sweetener to obtain a suspension. The suspension was then filtered sequentially first through a 0.45 micron and then through a 0.22 micron PTFE membrane.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06861060B1uspto-grants-2005_03