반응 #1068536

ord-e942178f3ccc4533bab9121451f5079e

반응 방정식

C[C@H]1C(Br)C(=O)C=C2C(Br)(CBr)C[C@@H]3[C@H](CC[C@]4(C)C(=O)CC[C@@H]34)[C@]21C
1α-methyl-2,6-dibromo-6-bromomethylandrost-4-ene-3,17-dione
[I-].[Na+]
sodium iodide
→
C=C1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@]2(C)C1=CC(=O)C(Br)[C@@H]2C
crude title compound
수율 90.1%
C=C1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@]2(C)C1=CC(=O)C(Br)[C@@H]2C
1α-Methyl-2-bromo-6-methylenandrost-4-ene-3,17-dione
수율 90.1%

반응물

C[C@H]1C(Br)C(=O)C=C2C(Br)(CBr)C[C@@H]3[C@H](CC[C@]4(C)C(=O)CC[C@@H]34)[C@]21C
1α-methyl-2,6-dibromo-6-bromomethylandrost-4-ene-3,17-dione
[I-].[Na+]
sodium iodide

시약

없음

용매

CC(C)=O
acetone

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

With a procedure similar to the one described in the Example 3, 2.5 g of 1α-methyl-2,6-dibromo-6-bromomethylandrost-4-ene-3,17-dione and 5.5 g of sodium iodide in acetone give 1.6 g of the crude title compound which is directly used for the next step.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04990635uspto-grants-1991_02