반응 #10665

반응 방정식

Intermediate 121

trans-N-(tert-butoxycarbonyl)-4-[(4-bromo-5-isoquinolyl)oxy]cyclohexylamine

tri(n-butyl)vinyltin

2,6-di-tert-butyl-p-cresol

→

title compound

trans-N-(tert-butoxycarbonyl)-4-[(4-vinyl-5-isoquinolyl)oxy]cyclohexylamine

용매

toluene

반응 조건

후처리

1. 1
   기타The solvent was evaporated under reduced pressure
2. 2
   기타the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=2:1)

실험 절차

A solution of Intermediate 121 (500 mg), tri(n-butyl)vinyltin (518 μl, Tokyo Kasei Kogyo), tetrakis(triphenylphosphine)palladium(0) (28.1 mg) and 2,6-di-tert-butyl-p-cresol (3.2 mg, Tokyo Kasei Kogyo) in toluene (10 ml) was stirred at 110° C. for 3 hours. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=2:1) to obtain the title compound (409.5 mg).

출처