반응 #1066298

반응 방정식

Ethyl 1,6-dihydro-2-methylthio-6-oxo-5pyrimidinecarboxylate

2,5-dimethylaniline

→

ethyl 1,6-dihydro-6-oxo-2-(2,5-dimethylanilino)-5-pyrimidinecarboxylate

수율 45.5%

용매

ethanol

반응 조건

후처리

1. 1
   온도the mixture is refluxed
2. 2
   온도After cooling
3. 3
   여과the precipitate is collected by filtration
4. 4
   기타recrystallized from DMF

실험 절차

Ethyl 1,6-dihydro-2-methylthio-6-oxo-5pyrimidinecarboxylate (10 g) and 2,5-dimethylaniline (8.5 g) are added to ethanol (150 ml), and the mixture is refluxed with stirring for 17 hours. After cooling, the precipitate is collected by filtration and recrystallized from DMF to give ethyl 1,6-dihydro-6-oxo-2-(2,5-dimethylanilino)-5-pyrimidinecarboxylate (6.1 g). M.p. 252°-254° C.

출처