반응 #10662
ord-77836b6fe0cb4c828f1476a14df81196
반응 방정식
반응 조건
온도
120°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1농축The reaction mixture was concentrated under reduced pressure
- 2기타the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1)
실험 절차
A suspension of Intermediate 121 (113.7 mg), zinc cyanide (19.4 mg, Wako Pure Chemical Industries), tris(dibenzylideneacetone)dipalladium(0) (24.0 mg) and 1,1′-bis(diphenylphosphino)ferrocene (35.3 mg, Tokyo Kasei Kogyo) in DMF (2 ml) was stirred at 120° C. for 19 hours. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1) to obtain the title compound (34.9 mg).