반응 #1061918

반응 방정식

NaHCO3

1,8-Octanediol

dihydropyran

HCl

→

crude product

수율 99.8%

8-[(Tetrahydro-2H-pyran-2-yl)oxy]-1-octanol

수율 99.8%

반응 조건

후처리

1. 1
   여과was filtered
2. 2
   기타Dichloromethane was removed with a rotary evaporator
3. 3
   기타the resulting residue was triturated with pentane
4. 4
   여과The solid was filtered from the pentane solution
5. 5
   기타the pentane was removed with a rotary evaporator

실험 절차

1,8-Octanediol (16.8 g) (115 mmol) and 4.83 g of dihydropyran (57.5 mmol) in 1400 ml of dichloromethane containing 5 drops of concentrated HCl were stirred for 2 hours. Then 10 g of NaHCO3 were stirred in and the solution was filtered. Dichloromethane was removed with a rotary evaporator, and the resulting residue was triturated with pentane; the undissolved solid was 1,8-octanediol. The solid was filtered from the pentane solution, and the pentane was removed with a rotary evaporator to give 13.2 g (99.8%) of crude product oil.

출처