반응 #1061098

반응 방정식

2-amino-4-chlorobenzonitrile

acetic anhydride

→

2-acetylamino-4-chlorobenzonitrile

용매

acetonitrile

반응 조건

후처리

1. 1
   온도by heating
2. 2
   기타After the completion of the reaction
3. 3
   workup.DISTILLATIONthe solvent was distilled off
4. 4
   workup.ADDITIONto the residue was added 500 ml of water
5. 5
   여과the crystals thus-deposited were collected by filtration
6. 6
   세척washed with water
7. 7
   기타dried

실험 절차

To 100 ml of acetonitrile were added 30 g of 2-amino-4-chlorobenzonitrile obtained in Step (2) and then 30 ml of acetic anhydride, and the mixture was refluxed by heating. After the completion of the reaction, the solvent was distilled off, then to the residue was added 500 ml of water, and the crystals thus-deposited were collected by filtration, washed with water and dried. Yield: 29 g (75.6%).

출처