반응 #1060761

반응 방정식

2-Chloro-4-(N-methylphenylamino)-6-methoxyquinazoline

4-fluoro-2-methylaniline

HCl

→

title compound

수율 54.3%

4-(N-Methylphenylamino)-2-(2-methyl-4-fluorophenylamino)-6-methoxyquinazoline

수율 54.3%

용매

ethanol

반응 조건

후처리

1. 1
   온도heated at 140° for 5 hours in a Berghof pressure reactor
2. 2
   온도The mixture was cooled
3. 3
   여과The precipitated solid was filtered off
4. 4
   기타recrystallised (isopropanol/ether followed by isopropanol)

실험 절차

2-Chloro-4-(N-methylphenylamino)-6-methoxyquinazoline (5.4 g, 0.02M) and 4-fluoro-2-methylaniline (4.96 g, 0.04M) were dissolved in ethanol (50 ml) and heated at 140° for 5 hours in a Berghof pressure reactor. The mixture was cooled and ethereal/HCl added. The precipitated solid was filtered off and recrystallised (isopropanol/ether followed by isopropanol) to yield the title compound (3.8 g) m.p. 248°-250°.

출처