반응 #1060760

반응 방정식

2-chloro-4-(N-methylphenylamino)-6methoxyquinazoline

o-toluidine

ethanol HCl

→

title compound

수율 57.7%

4-(N-methylphenylamino)-2-(2-methylphenylamino)-6-methoxyquinazoline hydrochloride

수율 57.7%

용매

ethanol

반응 조건

후처리

1. 1
   온도was heated in a Berchof pressure vessel at 140° for 5 hours (maximum pressure 40 psi)
2. 2
   온도After cooling
3. 3
   기타the solid which crystallised out
4. 4
   여과was filtered off
5. 5
   기타recrystallised from isopropanol/ether

실험 절차

A mixture of 2-chloro-4-(N-methylphenylamino)-6methoxyquinazoline (5.4 g, 0.027M), o-toluidine (4.28 g, 0.04M) in ethanol (50 ml) was heated in a Berchof pressure vessel at 140° for 5 hours (maximum pressure 40 psi). After cooling, ethanol/HCl was added and the solid which crystallised out was filtered off and recrystallised from isopropanol/ether to yield the title compound (4.23 g, m.p. 258°-260°).

출처