반응 #1059859

반응 방정식

p-fluoroacetophenone

N-propylpiperazine

potassium carbonate

→

p-(4-Propyl-1-piperazinyl)acetophenone

용매

dimethyl sulfoxide

반응 조건

후처리

1. 1
   workup.ADDITIONA mixture of 33.2 g
2. 2
   온도heated at 95° for 4.5 hours
3. 3
   온도cooled
4. 4
   여과The precipitate of p-(4-propyl-1-piperazinyl)-acetophenone is collected by filtration
5. 5
   세척washed with water
6. 6
   기타dried
7. 7
   기타m.p. 68°-70° after crystallization from hexane

실험 절차

A mixture of 33.2 g. of p-fluoroacetophenone, 48.3 g. of N-propylpiperazine and 99.5 g. of potassium carbonate in 100 ml. of dimethyl sulfoxide is stirred and heated at 95° for 4.5 hours, then cooled and poured into ice water. The precipitate of p-(4-propyl-1-piperazinyl)-acetophenone is collected by filtration, washed with water and dried; m.p. 68°-70° after crystallization from hexane.

출처